Macrophage death in atherosclerosis: potential role in calcification

نویسندگان

چکیده

Cell death is an important aspect of atherosclerotic plaque development. Insufficient efferocytosis cells by phagocytic macrophages leads to the buildup a necrotic core that impacts stability plaque. Furthermore, in presence calcium and phosphate, apoptotic bodies resulting from can act as nucleation sites for formation phosphate crystals, mostly form hydroxyapatite, which calcification plaque, further impacting stability. Excessive uptake cholesterol-loaded oxidized LDL particles present plaques foam cell formation, not only reduces their capacity, but also induce apoptosis these cells. The contribute Moreover, other forms macrophage death, such pyroptosis, necroptosis, parthanatos, ferroptosis similar mechanisms calcification. This review focuses on atherosclerosis, its potential role Reducing and/or increasing capacity could be novel therapeutic strategy reduce thereby improving

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ژورنال

عنوان ژورنال: Frontiers in Immunology

سال: 2023

ISSN: ['1664-3224']

DOI: https://doi.org/10.3389/fimmu.2023.1215612